There has been significant learning from studies of the basic biology of Hsp90, as well as translational drug development involving this chaperone, enhanced by the use of Hsp90 inhibitors as chemical probes. Here, we review the discovery and development of Hsp90 inhibitors and assess their potential. Many optimized synthetic, small-molecule Hsp90 inhibitors from diverse chemotypes are now in clinical trials. Preclinical data obtained with these natural products have heightened interest in Hsp90 as a drug target, and 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) has shown clinical activity (as defined by Response Evaluation Criteria in Solid Tumors) in HER2+ breast cancer. Investigators established Hsp90′s druggability using the natural products geldanamycin and radicicol, which mimic the unusual ATP structure adopted in the chaperone's N-terminal nucleotide-binding pocket and cause potent and selective blockade of ATP binding/hydrolysis, inhibit chaperone function, deplete oncogenic clients, and show antitumor activity. Originally viewed with skepticism, Hsp90 inhibitors are now being actively pursued by the pharmaceutical industry, with 17 agents having entered clinical trials. Heat shock protein (Hsp) 90 is an ATP-dependent molecular chaperone that is exploited by malignant cells to support activated oncoproteins, including many cancer-associated kinases and transcription factors, and it is essential for oncogenic transformation.
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![]() Take a look at your guidebook map when you get a chance: The amazing Take This organization organizes an AFK room to PAX events for years. I know you don’t want to miss anything, but just a little recovery time can really help you enjoy what you do get to see. Take time off the show floor for a while to get away from the noise or crowds. The summary of this section is to take breaks. Trust me, I’ll be enjoying a nice cocktail to toast with my friends, but binging on drinks of either kind can severely dehydrate you. On the other side, don't overdo it on caffeine or alcohol! I’ve seen both at other conventions, where people rely on substances to sustain or enhance the convention experience to the point of pain. You want to enjoy yourself? Power your body. Time for the basics: while at a convention, remember to eat! I’m not just talking chips or a convention hot dog either, but full meals with plenty of water. Still, it’s so very important to know your limits! The biggest change for me is how the expo hall is blessedly quieter you don't have various gaming booths competing for attention with loudspeakers blasting EDM or gunshot blasts. The lines aren’t as long, the crush of people isn’t as huge, and the main events don’t go as long into the night. With that in mind, Unplugged is going to be a slightly tamer experience than a video game convention. Knowing your limits and making room for down time in your schedule can be a livesaver, especially if you are going for the whole weekend. I had another friend who had anxiety attacks from the constant crowds without any breaks. I had a great time, but I’ll be honest and say that I spent the next week with flu-like symptoms, grumbling my way through work. I was able to manage just fine, but I was also 10 years younger and hopped up on Red Bull. We stayed until 1:30am to see everything we absolutely could, then woke up at 8 AM the next day to go wait in line on Saturday, just to stay again until 2 AM. The first convention I ever went to involved me driving to Boston on Friday for 4 hours after a day of work. This point gets put at the top, just because it can be so easily forgotten. #1: Before Everything Else, Take Care Of Yourself! With these questions in mind, here is our brand new guide to surviving – and enjoying – PAX Unplugged. For someone brand new to gaming conventions, it might be too much: where do you start? Where do you end? How do you know if you’ve gotten your money’s worth? For you veterans out there, maybe you are new to this particular convention, and want a few tips about good places to eat or relax. Still, if you have never been to a convention quite as large as a PAX, it’s still a lot to take in. While you see less flashing lights and glitzy displays, it also means you don’t end each day exhausted. PAX Unplugged is a convention that’s all about the board games, the tabletop, the analog it moves slower, but that doesn’t mean less fun. ![]() While Unplugged is a bit more established now, it's still a calmer, less rushed tempo than others we've been to. The crowds aren’t quite as large, developers and organizers are still trying to figure out the right tempo there’s less of a rush to it all. At this point, our staff enjoys it more than PAX East! There’s good reason for that though: there’s a certain magic to seeing a game convention in its early years. We were fortunate enough to go, and we had an absolute blast. ![]() ![]() In 2017, PAX Unplugged launched in Philadelphia. Still, PAX East is now a titan, a behemoth with 60,000 people, something that was overwhelming for those gamers new to conventions. It let us forget about reality, forget the stress of new jobs, and let us revel with a few thousand like-minded people. It was our sojourn, our chance to get out of New York for a long weekend. To prepare for PAX Unplugged 2022 on December 2nd, we've updated the article with some new hints and tips! We hope you find it useful.Ī few years ago, Zoë and I wrote a guide to our favorite convention, PAX East. This article was first published on November 27th, 2018. But there are a few disadvantages to renting a studio space in the city, including its notorious traffic and high real estate costs. When you take into account the city’s thriving live music scene, Los Angeles is one of the best places in the United States to record music. Pros and Cons of Recording in Los Angeles They can provide professional live audio services and all equipment, no matter how big or small your gig. Providing high-quality audio systems for a range of events, Westknolls Pro-Audio is a leading name in Los Angeles’ sound tech industry. It was founded by Uri Singer, who has won multiple awards for his production services and comprises a team of highly-experienced professionals in the audio-visual industry. ![]() They can turn their hands to a wide range of events, from corporate parties to weddings and recording sessions.īased in Los Angeles, Passage Pictures is one of the city’s leading production companies in the television and film industries. ![]() This Los Angeles event management company is based on Sunset Boulevard and has been serving the city for more than 20 years. recording session? There are plenty of event management companies, sound engineers, and audio rental businesses that can help. Some of Los Angeles’ bars and clubs are well equipped for hosting recordings and can be rented for private sessions on request. They’re a great option if you’re making recordings accompanied by music videos. Want an incredible view? Los Angeles boasts several open-air terraces and rooftops where you can set up your recording space. They come with all the sound and audio gear you need, as well as green rooms or behind-the-scenes spaces for your crew to utilize. Los Angeles’ studios are an obvious choice as a recording space, with most purpose-built for filming or recording. They serve as a blank canvas for adding your creative touch, whether you’re looking for something gritty or a space that’s been beautifully restored. Offering an industrial-style setting, Los Angeles’ warehouses are the ideal location for a recording studio. There’s a huge range of diversity in architectural styles and aesthetics, ensuring you can find a space to inspire your creativity. When you’re looking for a recording studio space in Los Angeles, there are plenty of options to consider.įrom downtown lofts to hillside homes, you can find a variety of recording studio spaces in Los Angeles to meet your needs. ![]() As a result, there is an abundance of recording studio spaces in Los Angeles where you can host sessions, no matter the style or genre of music you’re creating. is also a major center for the music industry, with both American and international artists choosing the city's recording studios to create their albums. It’s home to countless celebrities as the main hub of the American film industry and boasts exceptional museums that delve into the worlds of art, science, and history. Boasting a sun-drenched setting on the coast of Southern California, Los Angeles is one of the world’s most iconic cities. The Grand is also a bit heavier, and much more expensive. and that size (especially the width) makes it much less suitable for co-sleeping (more on that later) than the Deluxe+. The biggest differences between the Deluxe+ and Grand are the recommended baby ages and weights, and their overall sizes. It was a bit challenging to measure the side height because it really depends on how much loft the padding has at the moment, so take those measurements with a grain of salt! Here are the differences between the Deluxe+ and Grand DockATots: Early this year, we purchased both of them and put them to the test. There are two versions of the DockATot, the Deluxe+ and the Grand. These include the SwaddleMe By Your Side Sleeper, the Baby Delight Snuggle Nest, the Abreeze Bassinet Lounger, the CuddleNest, and the Smiling Gaia Baby Lounger Nest.Įach of these baby nests has its own pros and cons, and in our opinion none is as comfortable and versatile as the DockATot. It's not alone in the market, with several companies making products very similar to the DockATot. ![]() The DockATot was known in Europe as the SleepyHead, and then came to the United States in 2015. That's the origin of the term Moses basket, and artists' depiction of that frightful scene usually show something similar to a modern wicker Moses basket.įast-forward two thousand years and fortunately things have changed quite a bit!įirst and foremost, you won't be sending your baby down a river in a floating basket! But second, these baskets have gotten a lot more comfortable, versatile, safe, and easier to clean and maintain. Moses baskets are typically made of wicker with handles on the top, and lined with fabric and padding.īaby boxes are typically cardboard with a mattress placed at the bottom, and baby pods are more like nursing pillows with center support, like seen with the old recalled Boppy baby loungers.įor those familiar with the bible, Moses is said to have been left in a basket and set afloat along the Nile river (eek!). In general, a baby nest like the DockATot is similar to moses baskets, baby boxes (like the cardboard Smitten baby boxes), and baby pods. This isn't necessarily a new concept, it's just better executed with the DockATot. We review the safe and unsafe ways to use the DockATot later in the article, along with examples of ways that parents are using the DockATot in dangerous and inappropriate ways. This is your prerogative as a parent and nobody can stop you from choosing to co-sleep, but there are safe and very unsafe ways of co-sleeping. They also violate safe sleep recommendations of the American Academy of Pediatrics (AAP) and use it as a co-sleeper. Our biggest challenge with the DockATot is that parents don't read the instructions or use the product only as intended. Overall, we believe the pros outweigh the cons by a fairly big margin. That being said, we think there are a ton of practical and cozy uses for a DockATot! In other words, the DockATot is not a suitable replacement for an appropriately-sized bassinet or crib mattress. We advise against those uses, even if you're watching your baby closely in-person or with a baby monitor. When we first saw the DockATot, we were very nervous that parents would use it the wrong way: as an unsupervised sleeping area, as a co-sleeper, or placed into a crib or bassinet. ![]() The DockATot is the most popular baby nest on the market, offering a comfortable place for your baby or toddler to lounge, practice tummy time, get a diaper change, play, and have a supervised nap. ![]() You can read more about recent baby product recalls here and see the U.S. due to infant deaths associated with its use as a sleep product. ![]() If you buy products through links on our site, we may earn a commission.ĪLERT: As of November 2022, the DockATot Deluxe+ can no longer be manufactured, imported, or distributed to the U.S. Mommyhood101 independently tests and curates baby gear to help you make informed decisions. Other accessories such as posters, mugs, and cushion covers will bring life to your room just as Lil Peep himself added value to your life with his art. As a designer himself, Lil Peep left behind his ideas to his fans to open one day only to make them happy, so take his present to you and discover the true meaning behind each of them.Īdditionally, buying Lil Peep hoodies, shirts and other pieces of clothing will bring a sense of wholeness to your closet, while shoes will complete your entire look whenever you style an outfit. But you may also consider buying his merch from this Lil Peep website as a follower of a walking brand himself. Most fans buy it in his loving memory, others buy to show their loyalty to him. When all such numerous items come with premium quality and optimum prices to give you a complete experience of Lil Peep merch – are you willing to say no and not even look around our catalog? Why should you buy Lil Peep merch from Us? ![]() Our catalog is the most diverse in the market, providing you with phone cases, mugs, shirts, sweaters, hoodies, jackets, sweatpants, shoes, bags, caps, posters, pillowcases, and cushion covers. ![]() We promise not to disappoint you with our diverse offerings in which fan favorites include, ‘Come Over When You’re Sober Hellboy’ t-shirt and hoodie, ‘The Peep Show’ sweatpants, and the classic black and white beanie. ![]() So, join us in our journey where we bring Lil Peep to life for millions and ensure that every follower gets the perfect Lil Peep collection of their dreams. Lil Peep Merchandise – Welcome to Lil Peep Merch ShopĪs Lil Peep’s fame rises, so do the number of Lil Peep merch shops, but how many of them can guarantee superior quality, immense variety, and affordable rates amongst numerous other features? 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The o-rings, needles and gaskets were replaced. I've reapplied lubrication to pivots and all moving parts that were necessary. I've serviced the carburetors, completely disassembling them, ultrasonically cleaned every part. I have replaced the spark plugs with Denso Iridium, the best and properly gapped. The coolant has been changed and upgraded to Engine Ice for optimal cooling. It has had a fresh oil change recently with less than 500 miles on it. The steering bearings are tight and move smoothly with no issues. The chain and sprockets are in great shape, the chain has no kinks or tight spots and is well lubricated and adjusted to OEM specs. Everythings in excellent working order and this motorcycle needs absolutely nothing more than a new rider.The tires, brakes and battery are all in great shape. I have put a good amount of time into making sure this motorcycle is as good as it gets. Just to note, I have 5 years experience working for Triumph Motorcycles and have over 10 years experience working as a Motorcycle Technician. 1995 Triumph Daytona 900cc inline triple. Controller Support, play with your Gamepad. Request new maps and vehicles on our social media pages. Tilt steering, buttons and touch steering wheel. Bluestacks software is even available for Mac OS as well. Learn to drive a manual with clutch and stick shift. Driving School Sim Download for PC Windows 10/8/7 Method 1: Bluestacks is one of the coolest and widely used Emulator to run Android applications on your Windows PC. Different licenses to take, Car, Bus and Truck. Show off your driving skills, get your driving license now. These trends are not unique to the United The 2016 World Economic Forum. More than 50 levels with different driving situations are waiting for you. This that many, if not most, structure demand for routine and manual will need. 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The ministry recommends that all drivers would benefit from taking an advanced course in driver training.Īs you read, remember that this handbook is only a guide. ![]() This handbook gives new drivers the basic information they need about learning to drive in Ontario: the rules of the road, safe driving practices and how to get a licence to drive a car, van or small truck. Ontario’s Graduated Licensing System (GLS), which lets new drivers gain skills and experience in low-risk environments, is also helping to develop better, safer drivers. Provincial campaigns promoting the correct use of seatbelts and child car seats, and informing people about drinking and driving and aggressive driving, are making a difference. Statistics show that new drivers of all ages are far more likely than experienced drivers to be involved in serious or fatal collisions. There are also drivers who intentionally put others at risk through such reckless behaviour. You are able to install Driving School 2016 for PC by using BlueStacks Android emulator either by searching for Driving School 2016 app in playstore page or by using apk file. DRIVERS ED DRIVING SCHOOL PAMPANGA Brand new toyota vios (manual and automatic) Defensive driving. Most collisions are caused by driver error or behaviours such as following too closely, speeding, failure to yield the right of way, improper turns, running red lights and frequently changing lanes. ![]() ![]() The Ministry of Transportation has introduced a range of measures to maintain this record and to improve the behaviour of all drivers. Ontario is a road safety leader in Canada and North America. Demandez le « Guide officiel de l'automobiliste de publié par le MTO »ĭriving is a privilege - not a right Introduction To request a copy of this book in an alternate format, contact Publications Ontario at 1-80 or 41 or visit ServiceOntario Publications.ĭisponible en français. If you're taking beginner driver education, make sure it’s from a ministry-approved school.įor more information about driver licensing, visit Ministry of Transportation. For official purposes, please refer to the Highway Traffic Act, the Motorized Snow Vehicles Act and the Off-Road Vehicles Act of Ontario. ![]() Both binary and source packages are available from GitHub and our Download page. For Linux users, we provide a Flatpak package and a Ubuntu PPA and try to make compiling as easy as possible, and most distributions will pick up Widelands 1.0 into their repositories very quickly. Widelands is distributed for Windows (64-bit and 32-bit) and Mac OS X >= 10.7 (Intel, 64-bit) and in source code. Widelands 1.0 is translated completely into German, Hungarian and Low German, and the translations for 12 other languages are more than ⅔ complete. Long-term stable Lua API for game content designers.Enhanced keyboard and mousewheel support in the UI.Targeting individual map objects for removal.Dynamic tribe loading to speed up game loading.Since the release of Build 21, we implemented several hundreds of new features and bugfixes for example, to name just a few of the highlights: The Widelands Development Team is proud to announce the immediate availability of the stable release Widelands 1.0, the first-ever stable release after the end of the beta Builds series. Both binary and source packages are available from and our Download page. Also, most distributions will pick up Build 21 into their repositories very quickly, and we provide a PPA for Ubuntu users. Instead, we try to make compiling for Linux users as easy as possible. ![]() We no longer ship binary Linux packages because of the poor compatibility between Linux distributions. Widelands is translated completely into Catalan, Danish, Dutch, Finnish, French, Scottish Gaelic, German, Low German, and Spanish and the translations for 9 other languages are more than ⅔ complete. Extensive behind-the-scenes source code cleanup and refactoring.Lots and lots of balancing tweaks to all tribes.Numerous fixes and improvements to the tutorials and scenarios.Spritesheets and mipmaps provide high-quality graphics when zooming in.Changing settings for buildings in the constructionsite.New planning-ahead ship scheduling algorithm.Allow the player to choose the soldiers to send in the attack box.More detailed user controls for game speed, map scrolling, and many properties of building windows new hotkeys re-added quick navigation with ‘,’ and ‘.’ partly redesigned and modernized user interface.New “Peaceful Mode” and several new starting conditions.Since the release of Build 20, we implemented several hundreds of new features and bugfixes, for example: After the successful installation of Widelands real time strategy game, click the show applications in the Ubuntu Gnome dock and type Widelands in the search box and click Widelands to open it.The Widelands Development Team is proud to announce the immediate availability of Widelands Build 21. sudo apt-get install widelandsĭuring the installation of Widelands RTS game press y and enter to confirm the installation. Then in terminal, run the below command to install the latest version of Widelands real time strategy game on ubuntu. Then type the below command press the enter key to update your package list on ubuntu system. Type your Ubuntu password if needed and hit the ENTER key to confirm the addition of Widelands real time strategy game PPA on your system. sudo add-apt-repository ppa:widelands-dev/widelands Open terminal app (Ctrl+Alt+T) and type the below command and hit the enter key. To install via PPA, first you need to add its PPA on Ubuntu via below command. You can install Widelands real time strategy game on Ubuntu via its official PPA. ![]() If you have any questions about this item, please click to send us an email. Stormscope or, better yet, a radar system understand the differ. Test function to verify proper operation.Clear function to help determine storm intensity and movement.Internal lighting for night / low-light operations. ![]() You won't necesarily be able to make out a specific cell, but you will be able to give the thunderstorms the distance they demand. >Heading is not required by the GTN however, to take full advantage of the GTN unit capabilities, an optional heading source is recommended to provided autopilot roll steering on ARINC 424 heading legs, to display TAS traffic and WX-500 Stormscope data on the moving map, and to calculate winds if airspeed is also available. It is designed to help a pilot detect dangerous activity and stay well clear. The WX-8's display is less precise than other Stormscope displays. When activity is detected, these segments will show a steady color, flash slowly, or flash quickly (in increasing activity level). Instead of a round green CRT tube, the WX-8 uses a three color LCD to show thunderstorm activity in the 135° of airspace in front of your aircraft.Įach segment is 15 degrees wide. The WX-8 display is different from other Stormscopes that you have seen. This was a two-piece system consisting of a display/processor and an antenna. ![]() The WX-8 Stormscope was the most affordable Stormscope solution. This Supplement must be inserted in the applicable FAA Approved Pilots Operating Handbook and Airplane Flight Manual (POHIAFM) when the StormscopeQ WX-500. The system consists of an antenna located on top of the fuselage just forward of the rear window and a processor unit mounted under the aft baggage floor. However the antenna cables needed for a complete systems are almost non-existant. The L-3 Avionics Systems WX-500 Weather Mapping Sensor (Stormscope) detects electrical discharges associated with thunderstorms and displays the activity on the Multi-Function Display. The Stormscope has been through many model iterations since inventor and pilot Paul Ryan developed it during the 1970s. We may be able to locate an Antenna ( P/N: 78-8041-7905-5) if needed. The best fit for this item is a customer who needs to replace a malfunctioning WX-8 Display / Processor, and does not want to perform a new installation (such as the WX-500). ![]() I got chills / They’re multiplyin’ / And I’m losin’ control / ’Cause the power you’re supplyin’ / It’s electrifyin’ - “You're The One That I Want” written by John Farrar RANK ON ALL-TIME BOXOFFICE LIST AT CLOSE OF ORIGINAL RUN: 4ĬUMULATIVE DOMESTIC BOXOFFICE GROSS INCLUDING RE-RELEASES: $188.3 million OPENING-WEEKEND BOXOFFICE GROSS: $8.9 millionĬUMULATIVE DOMESTIC BOXOFFICE GROSS OF ORIGINAL 1978 RUN: $132.5 million SCREENPLAY: Bronte Woodard (Screenplay), Allan Carr (Adaptation), Jim Jacobs and Warren Casey (Original Musical) Visit biografmuseet.dk about Danish cinemasĬompiled by: Michael Coate, Hollywood, USAĪ quick-reference tribute to the most-popular movie musical ever made… Parts of may be reprinted with the written permission fromĬopyright © 1800 - 2070. Readers and fans of 70mm are always welcome , a unique internet based magazine, with articles about 70mmĬinemas, 70mm people, 70mm films, 70mm sound, 70mm film credits, 70mm Making and during running the films in projection rooms and as the To record the history of the large format movies and the 70mm cinemasĪs remembered by the people who worked with the films."Having that Indigenous representation I feel is very important to show our youth and our young people that it's great to be proud of who you are, your identity and where you come from," McGuire said. Dakota wears a red jingle dress on stage to remember her and other missing and murdered Indigenous women, girls and two-spirit people. ![]() When McGuire was a baby, her mother, Jamie, was killed near Winnipeg. Lightning described an interaction with an older Navajo woman who went to see the show in Las Vegas, and noted that during the 1950s and '60s, Indigenous people faced discrimination and racism, which meant they felt they couldn't dance and sing in public like the characters do in the show.ĭakota McGuire, an actor from Thunder Bay who plays Patty Simcox, also sees a bigger purpose in the show. Still, for some older audience members, the show has a deeper meaning. Video Experience the Wake the Giant music festival with CBC's Sara Kaeīear Grease is not just for Indigenous people, though, and Lightning and her husband have received many positive reviews from non-Indigenous audience members who laughed and enjoyed the story all the way through. They were requested to play at the Edmonton Fringe, a theatre festival based out of the Alberta capital, when they decided to dust off the script for Bear Grease to get it ready within a month of the performance. Lightning and RedCloud initially wrote Bear Grease for students at a school in Enoch Cree First Nation, but the pandemic forced them to shelve the idea. She landed roles in American Pie Presents: Bandcamp, Yellowstone and Outlander. In 2021, she won the award for best actress in a drama series for her role as Maggie in Trickster. He used the opportunity to bring awareness to murdered and missing Indigenous women, girls and two-spirit people.Ĭrystle is originally from Enoch Cree First Nation in central Alberta, but moved to Hollywood as a young child to pursue her acting career. RedCloud is a rapper who set a Guinness World Record for the longest freestyle rap - for 18 hours straight - in 2014. Together, they have worked with notable names such as Timbaland, Kendrick Lamar and Nicki Minaj. Lightning and RedCloud (also known as Henry Andrade) met in California, where they formed their hip-hop duo, Lightning Cloud. "There is a little something for everyone in Bear Grease," Lightning said. There's also a touch of hip hop, to help Bear Grease appeal to younger audiences. The music has been kept in '50s style, but drums and flutes are brought in to demonstrate more traditional aspects of the culture. "We don't want to just be for Native audiences," Lightning said. But Bear Grease was written to give each character Indigenous influence, with elements of fashion, humour and music to really make it their own, Lightning explained. The cast has familiar characters - such as Sandy (played by Olivia Newton-John), Rizzo (Stockard Channing) and Danny (John Travolta). Their travelling theatre production is called Bear Grease - an Indigenous twist on the traditional story of high school love. So along with her husband, MC Redcloud, Lightning thought there was no better way to celebrate their identity, in spaces where they felt Indigenous representation was excluded, than by revamping one of their favourite musicals - Grease. Crystle Lightning says she never saw people like herself reflected in the arts and media. |
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